ZWILCH | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	18% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZWILCH at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	440.42	170 / 170	100%	20.52	458 / 459
esophagus	100%	447.09	1438 / 1445	100%	21.08	183 / 183
bladder	100%	382.95	21 / 21	99%	13.38	501 / 504
breast	100%	475.47	459 / 459	99%	14.04	1111 / 1118
ovary	100%	535.94	180 / 180	99%	10.56	426 / 430
lung	99%	419.80	574 / 578	99%	13.24	1143 / 1155
stomach	100%	330.59	359 / 359	98%	14.19	281 / 286
intestine	100%	397.80	965 / 966	98%	14.34	518 / 527
prostate	100%	377.81	245 / 245	95%	6.88	479 / 502
skin	100%	932.19	1809 / 1809	95%	13.94	450 / 472
pancreas	97%	242.23	318 / 328	93%	7.90	166 / 178
thymus	100%	342.21	652 / 653	84%	5.09	509 / 605
kidney	100%	345.00	89 / 89	73%	4.09	662 / 901
brain	96%	301.76	2533 / 2642	77%	6.09	542 / 705
adrenal gland	100%	271.89	257 / 258	60%	3.29	139 / 230
liver	98%	196.89	222 / 226	59%	3.65	240 / 406
lymph node	0%	0	0 / 0	100%	12.83	29 / 29
spleen	100%	572.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.52	45 / 45
ureter	0%	0	0 / 0	100%	6.85	1 / 1
blood vessel	100%	389.97	1334 / 1335	0%	0	0 / 0
adipose	100%	451.00	1201 / 1204	0%	0	0 / 0
muscle	99%	211.48	793 / 803	0%	0	0 / 0
heart	89%	166.32	766 / 861	0%	0	0 / 0
peripheral blood	66%	589.64	610 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	2.47	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0034501	Biological process	protein localization to kinetochore
GO_0051988	Biological process	regulation of attachment of spindle microtubules to kinetochore
GO_0051301	Biological process	cell division
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_1990423	Cellular component	RZZ complex
GO_0000776	Cellular component	kinetochore
GO_0005828	Cellular component	kinetochore microtubule
GO_0005829	Cellular component	cytosol
GO_0005515	Molecular function	protein binding

Gene name	ZWILCH
Protein name	Protein zwilch homolog (hZwilch) Protein zwilch Protein zwilch homolog
Synonyms
Description	FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex . . FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. . FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. .
Accessions	ENST00000564179.5 ENST00000565627.5 [Q9H900-2] Q9H900 H3BPI7 ENST00000569489.1 ENST00000446801.6 [Q9H900-2] H3BQ07 ENST00000613446.4 [Q9H900-2] ENST00000535141.6 [Q9H900-2] ENST00000567816.1 ENST00000307897.10 [Q9H900-1] H3BSG1

ZWILCH report