I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 33% ± 10% | |
| GABAergic neuron | 3 studies | 31% ± 2% | |
| oligodendrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 33% ± 10% | |
| GABAergic neuron | 3 studies | 31% ± 2% | |
| oligodendrocyte | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 28% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 502.70 | 1445 / 1445 | 100% | 12.80 | 183 / 183 |
| lung | 100% | 755.58 | 578 / 578 | 100% | 11.32 | 1155 / 1155 |
| breast | 100% | 577.29 | 459 / 459 | 100% | 14.26 | 1117 / 1118 |
| brain | 100% | 467.91 | 2637 / 2642 | 100% | 13.45 | 705 / 705 |
| bladder | 100% | 475.86 | 21 / 21 | 100% | 10.95 | 503 / 504 |
| prostate | 100% | 489.43 | 245 / 245 | 100% | 9.83 | 501 / 502 |
| uterus | 100% | 436.10 | 170 / 170 | 100% | 12.40 | 458 / 459 |
| intestine | 100% | 519.79 | 966 / 966 | 99% | 12.20 | 524 / 527 |
| thymus | 100% | 546.04 | 653 / 653 | 99% | 10.04 | 600 / 605 |
| ovary | 100% | 304.44 | 180 / 180 | 99% | 6.58 | 426 / 430 |
| stomach | 100% | 430.50 | 359 / 359 | 99% | 11.23 | 283 / 286 |
| pancreas | 100% | 366.00 | 328 / 328 | 99% | 9.55 | 176 / 178 |
| kidney | 100% | 395.21 | 89 / 89 | 99% | 7.83 | 890 / 901 |
| adrenal gland | 100% | 470.72 | 258 / 258 | 98% | 14.98 | 225 / 230 |
| liver | 100% | 292.21 | 225 / 226 | 95% | 5.37 | 387 / 406 |
| skin | 100% | 762.58 | 1809 / 1809 | 93% | 8.55 | 439 / 472 |
| adipose | 100% | 565.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.08 | 29 / 29 |
| spleen | 100% | 659.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 10.89 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.21 | 1 / 1 |
| blood vessel | 100% | 433.00 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 97% | 213.40 | 782 / 803 | 0% | 0 | 0 / 0 |
| heart | 95% | 220.71 | 822 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 88% | 565.89 | 817 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 4.37 | 60 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005515 | Molecular function | protein binding |
| GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | ZUP1 |
| Protein name | Zinc finger containing ubiquitin peptidase 1 Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein) Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (Zinc finger with UFM1-specific peptidase domain protein) |
| Synonyms | ZUFSP C6orf113 hCG_21762 |
| Description | FUNCTION: Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains . Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage . Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress . . |
| Accessions | ENST00000368573.5 ENST00000368576.8 [Q96AP4-1] Q96AP4 A0A0S2Z605 X6R6X3 A0A0S2Z623 A0A0S2Z644 |
