ZNG1C report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNG1C at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0016787Molecular functionhydrolase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNG1C
Protein nameZn regulated GTPase metalloprotein activator 1C (Zn regulated GTPase metalloprotein activator 1E)
Zn regulated GTPase metalloprotein activator 1C
Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3)
Zn regulated GTPase metalloprotein activator 1C (Zn regulated GTPase metalloprotein activator 1E) (Zn regulated GTPase metalloprotein activator 1F)
SynonymsCBWD3
ZNG1F
ZNG1E
DescriptionFUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. .

AccessionsENST00000613716.5
Q5JTY5
A0A087WYD2
ENST00000615061.4
ENST00000618217.4
ENST00000465474.5
A0A087WWG3
A0A0A0MRU4
ENST00000377389.5
ENST00000360171.11 [Q5JTY5-1]
ENST00000622755.4
F2Z3P0
ENST00000377349.6
ENST00000469921.5
ENST00000612050.4
ENST00000377342.9
Q5RIB5
ENST00000377384.5
ENST00000611426.4
ENST00000478048.5