ZNG1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0016787Molecular functionhydrolase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNG1B
Protein nameZinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)
Zn regulated GTPase metalloprotein activator 1B
SynonymsCBWD2
DescriptionFUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1B to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. .

AccessionsQ8IUF1
C9J3G2
ENST00000358604.7
ENST00000456188.5
F8WFD0
ENST00000416503.6
ENST00000259199.9
F8WEU0