ZNF445 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044726Biological processepigenetic programing of female pronucleus
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0010385Molecular functiondouble-stranded methylated DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF445
Protein nameZinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15)
SynonymsZNF168
ZFP445
ZKSCAN15
DescriptionFUNCTION: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) . Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance . .

AccessionsENST00000396077.8
ENST00000425708.6
P59923