ZFYVE19 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZFYVE19 at tissue level.

III. Associated gene sets

GO_0032466Biological processnegative regulation of cytokinesis
GO_0044878Biological processmitotic cytokinesis checkpoint signaling
GO_0051301Biological processcell division
GO_0009838Biological processabscission
GO_0090543Cellular componentFlemming body
GO_0005813Cellular componentcentrosome
GO_0032154Cellular componentcleavage furrow
GO_0030496Cellular componentmidbody
GO_0005737Cellular componentcytoplasm
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZFYVE19
Protein nameZinc finger FYVE-type containing 19
Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19)
SynonymsMPFYVE
ANCHR
DescriptionFUNCTION: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. .

AccessionsENST00000566767.1
ENST00000355341.8 [Q96K21-1]
H3BP54
ENST00000570108.5
H3BS07
ENST00000568062.5
H3BN64
ENST00000561617.1
ENST00000567756.5
Q96K21
ENST00000561768.5
H3BRM1
ENST00000564258.5 [Q96K21-4]
ENST00000299173.14 [Q96K21-3]
ENST00000336455.9 [Q96K21-2]
ENST00000569057.5
ENST00000566407.5
H3BRF9
H3BSF5
H3BVF5
H3BUW6