ZFP57 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZFP57 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZFP57 at tissue level.

III. Associated gene sets

GO_0141068Biological processautosome genomic imprinting
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameZFP57
Protein nameZFP57 zinc finger protein
ZFP57 protein
Zinc finger protein 57 homolog
Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698)
SynonymsZNF698
C6orf40
DescriptionFUNCTION: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) . Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance . Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). .

AccessionsENST00000547911.2 [Q9NU63-1]
ENST00000437216.5 [Q9NU63-2]
ENST00000552898.2 [Q9NU63-1]
ENST00000548001.2 [Q9NU63-1]
ENST00000552987.2 [Q9NU63-1]
ENST00000488757.6
A0A140T983
ENST00000376883.2 [Q9NU63-3]
ENST00000552809.1 [Q9NU63-3]
ENST00000432222.1
ENST00000416974.5 [Q9NU63-2]
ENST00000549167.1 [Q9NU63-3]
ENST00000383628.6 [Q9NU63-2]
ENST00000553137.1 [Q9NU63-3]
B7ZW61
ENST00000547542.2 [Q9NU63-1]
ENST00000548574.1 [Q9NU63-3]
A0A7I2S1M6
ENST00000548337.1 [Q9NU63-3]
ENST00000548769.1 [Q9NU63-3]
ENST00000448114.5 [Q9NU63-2]
Q9NU63
ENST00000435906.5 [Q9NU63-2]
ENST00000446005.5 [Q9NU63-2]
ENST00000549501.2 [Q9NU63-1]