ZDHHC19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZDHHC19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZDHHC19 at tissue level.

III. Associated gene sets

GO_1905337Biological processpositive regulation of aggrephagy
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0097356Cellular componentperinucleolar compartment
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC19
Protein namePalmitoyltransferase ZDHHC19 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 19) (DHHC-19)
Synonyms
DescriptionFUNCTION: Palmitoyltransferase that mediates palmitoylation oproteins, such as RRAS and SQSTM1 . Catalyzes palmitoylation of RRAS, leading to increased cell viability . Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes . .; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. .

AccessionsENST00000438232.5 [Q8WVZ1-2]
ENST00000296326.8 [Q8WVZ1-1]
ENST00000397544.6 [Q8WVZ1-3]
Q8WVZ1