ZAR1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZAR1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	50%	7.48	1315 / 2642	4%	0.08	31 / 705
bladder	33%	2.14	7 / 21	3%	0.04	14 / 504
lung	33%	2.64	189 / 578	2%	0.05	23 / 1155
blood vessel	34%	4.44	448 / 1335	0%	0	0 / 0
skin	20%	4.52	368 / 1809	1%	0.01	3 / 472
intestine	14%	0.68	138 / 966	4%	0.06	19 / 527
stomach	14%	0.62	49 / 359	4%	0.07	11 / 286
ovary	17%	9.30	30 / 180	0%	0	0 / 430
thymus	14%	0.66	93 / 653	1%	0.02	6 / 605
uterus	8%	0.65	13 / 170	7%	0.16	30 / 459
prostate	11%	0.50	28 / 245	0%	0.00	1 / 502
esophagus	4%	0.18	60 / 1445	5%	0.14	9 / 183
tonsil	0%	0	0 / 0	7%	0.15	3 / 45
adrenal gland	4%	0.17	10 / 258	3%	0.04	6 / 230
pancreas	5%	0.19	16 / 328	1%	0.01	1 / 178
kidney	4%	0.20	4 / 89	0%	0	0 / 901
adipose	4%	0.28	51 / 1204	0%	0	0 / 0
heart	4%	0.14	33 / 861	0%	0	0 / 0
peripheral blood	4%	0.16	34 / 929	0%	0	0 / 0
breast	3%	0.12	13 / 459	0%	0.00	2 / 1118
spleen	3%	0.12	7 / 241	0%	0	0 / 0
muscle	3%	0.11	23 / 803	0%	0	0 / 0
liver	1%	0.04	3 / 226	0%	0.01	1 / 406
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001556	Biological process	oocyte maturation
GO_0006412	Biological process	translation
GO_0140694	Biological process	non-membrane-bounded organelle assembly
GO_0048255	Biological process	mRNA stabilization
GO_0017148	Biological process	negative regulation of translation
GO_0043232	Cellular component	intracellular non-membrane-bounded organelle
GO_0005737	Cellular component	cytoplasm
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0140610	Molecular function	RNA sequestering activity
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

Gene name	ZAR1
Protein name	Zygote arrest 1 Zygote arrest protein 1
Synonyms
Description	FUNCTION: mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation. .
Accessions	Q86SH2 ENST00000327939.4 B9EG67

ZAR1 report