YRDC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of YRDC at tissue level.

III. Associated gene sets

GO_0002949Biological processtRNA threonylcarbamoyladenosine modification
GO_0051051Biological processnegative regulation of transport
GO_0006450Biological processregulation of translational fidelity
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0061710Molecular functionL-threonylcarbamoyladenylate synthase
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameYRDC
Protein nameThreonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)
SynonymsDRIP3
IRIP
DescriptionFUNCTION: Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate . Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs . May regulate the activity of some transporters (By similarity). .

AccessionsENST00000373044.3
Q86U90