YOD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of YOD1 at tissue level.

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0035523Biological processprotein K29-linked deubiquitination
GO_1990168Biological processprotein K33-linked deubiquitination
GO_0016236Biological processmacroautophagy
GO_1990167Biological processprotein K27-linked deubiquitination
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_1904153Biological processnegative regulation of retrograde protein transport, ER to cytosol
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0016579Biological processprotein deubiquitination
GO_0035871Biological processprotein K11-linked deubiquitination
GO_0036503Biological processERAD pathway
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0101005Molecular functiondeubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYOD1
Protein nameUbiquitin thioesterase OTU1 (EC 3.4.19.12) (DUBA-8) (HIV-1-induced protease 7) (HIN-7) (HsHIN7) (OTU domain-containing protein 2)
SynonymsHIN7
PRO0907
DUBA8
OTUD2
DescriptionFUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation . .

AccessionsENST00000367084.1 [Q5VVQ6-2]
Q5VVQ6
ENST00000315927.9 [Q5VVQ6-1]