YJU2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of YJU2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of YJU2 at tissue level.

III. Associated gene sets

GO_0008380Biological processRNA splicing
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0000349Biological processgeneration of catalytic spliceosome for first transesterification step
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameYJU2
Protein nameSplicing factor YJU2 (Coiled-coil domain-containing protein 94)
YJU2 splicing factor homolog
SynonymsCCDC94
DescriptionFUNCTION: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA . Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex . .

AccessionsENST00000262962.12
M0R2S3
ENST00000596496.1
Q9BW85