YEATS4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000278Biological processmitotic cell cycle
GO_2000779Biological processregulation of double-strand break repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007010Biological processcytoskeleton organization
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0051726Biological processregulation of cell cycle
GO_0000786Cellular componentnucleosome
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0016363Cellular componentnuclear matrix
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0140030Molecular functionmodification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYEATS4
Protein nameYEATS domain containing 4
YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1)
SynonymsGAS41
DescriptionFUNCTION: Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) . Also able to recognize and bind crotonylated histone H3 . May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo . Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z . H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity). .

AccessionsO95619
ENST00000552955.1
ENST00000549685.5
F8W0J4
F8W1B9
ENST00000548020.5
ENST00000247843.7
F8VTR4