XPOT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0006409Biological processtRNA export from nucleus
GO_0071528Biological processtRNA re-export from nucleus
GO_0016363Cellular componentnuclear matrix
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005643Cellular componentnuclear pore
GO_0005737Cellular componentcytoplasm
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameXPOT
Protein nameExportin-T (Exportin(tRNA)) (tRNA exportin)
Synonyms
DescriptionFUNCTION: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. .

FUNCTION: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. .

FUNCTION: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. .

FUNCTION: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. .

AccessionsO43592
F8WDU6
ENST00000332707.10
F5GZM3
ENST00000538086.5
ENST00000540203.5
ENST00000400935.2
F5GYW6