WRAP73 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WRAP73 at tissue level.

III. Associated gene sets

GO_1902857Biological processpositive regulation of non-motile cilium assembly
GO_0090307Biological processmitotic spindle assembly
GO_0030030Biological processcell projection organization
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0005815Cellular componentmicrotubule organizing center
GO_0036064Cellular componentciliary basal body
GO_0034451Cellular componentcentriolar satellite
GO_1990811Cellular componentMWP complex
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWRAP73
Protein nameWD repeat containing, antisense to TP73
WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)
WD repeat containing, antisense to TP73 (WD repeat domain 8, isoform CRA_c)
SynonymshCG_20082
WDR8
DescriptionFUNCTION: The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology . Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles . .

AccessionsA0A0A0MRV3
ENST00000424367.5
Q5T0D5
ENST00000270708.12
ENST00000378322.7
Q5TBW1
ENST00000465916.5
J3KTP2
ENST00000419924.2
Q9P2S5