WEE2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of WEE2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WEE2 at tissue level.

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0006468Biological processprotein phosphorylation
GO_1900194Biological processnegative regulation of oocyte maturation
GO_0000278Biological processmitotic cell cycle
GO_0007143Biological processfemale meiotic nuclear division
GO_0060631Biological processregulation of meiosis I
GO_0035038Biological processfemale pronucleus assembly
GO_0080154Biological processregulation of fertilization
GO_0005829Cellular componentcytosol
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameWEE2
Protein nameWee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase)
SynonymsWEE1B
DescriptionFUNCTION: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II . Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). .

AccessionsENST00000397541.6
ENST00000576319.1
P0C1S8
ENST00000493845.1
H7C5P0
ENST00000574659.5