WDR91 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042176Biological processregulation of protein catabolic process
GO_0045022Biological processearly endosome to late endosome transport
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010008Cellular componentendosome membrane
GO_0031901Cellular componentearly endosome membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005829Cellular componentcytosol
GO_0035014Molecular functionphosphatidylinositol 3-kinase regulator activity
GO_0141039Molecular functionphosphatidylinositol 3-kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR91
Protein nameWD repeat domain 91
WD repeat-containing protein 91
SynonymsHSPC049
DescriptionFUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport . It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome . May play a role in meiosis (By similarity). .

AccessionsA4D1P6
ENST00000682802.1
ENST00000354475.5 [A4D1P6-1]
ENST00000682250.1
ENST00000683947.1
A0A804HI90
ENST00000423565.5
ENST00000683848.1
A0A804HKV2
ENST00000684322.1
ENST00000684339.1 [A4D1P6-2]
A0A804HHS8
C9J1X0
A0A804HJP3