WDR81 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	3 studies	19% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of WDR81 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	3689.10	1809 / 1809	100%	45.44	470 / 472
esophagus	100%	2291.67	1439 / 1445	99%	22.08	182 / 183
kidney	100%	2077.49	89 / 89	98%	22.90	884 / 901
thymus	100%	2745.59	653 / 653	98%	14.48	593 / 605
prostate	100%	3554.03	245 / 245	98%	15.20	490 / 502
breast	100%	3896.32	459 / 459	97%	15.35	1089 / 1118
intestine	100%	3006.07	966 / 966	97%	13.20	513 / 527
uterus	100%	4331.75	170 / 170	97%	12.57	444 / 459
bladder	100%	3450.71	21 / 21	97%	13.85	487 / 504
liver	100%	2928.33	226 / 226	97%	14.85	392 / 406
lung	99%	3473.58	573 / 578	97%	16.68	1125 / 1155
stomach	99%	1999.38	357 / 359	97%	15.20	276 / 286
pancreas	97%	1407.53	318 / 328	98%	15.88	174 / 178
brain	94%	1121.79	2489 / 2642	99%	19.52	699 / 705
ovary	100%	4437.27	180 / 180	87%	11.45	373 / 430
adrenal gland	100%	3341.72	258 / 258	82%	8.97	188 / 230
adipose	100%	3713.34	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	64.95	80 / 80
lymph node	0%	0	0 / 0	100%	31.28	29 / 29
spleen	100%	5271.34	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.39	45 / 45
ureter	0%	0	0 / 0	100%	5.83	1 / 1
muscle	100%	2374.31	801 / 803	0%	0	0 / 0
blood vessel	99%	2162.51	1323 / 1335	0%	0	0 / 0
heart	96%	1331.04	823 / 861	0%	0	0 / 0
peripheral blood	95%	1595.99	882 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0007005	Biological process	mitochondrion organization
GO_0045022	Biological process	early endosome to late endosome transport
GO_0035973	Biological process	aggrephagy
GO_0050821	Biological process	protein stabilization
GO_0010008	Cellular component	endosome membrane
GO_0031901	Cellular component	early endosome membrane
GO_0000421	Cellular component	autophagosome membrane
GO_0031902	Cellular component	late endosome membrane
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005765	Cellular component	lysosomal membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0035014	Molecular function	phosphatidylinositol 3-kinase regulator activity
GO_0141039	Molecular function	phosphatidylinositol 3-kinase inhibitor activity
GO_0070530	Molecular function	K63-linked polyubiquitin modification-dependent protein binding
GO_0005515	Molecular function	protein binding

Gene name	WDR81
Protein name	WD repeat domain 81 (WD repeat-containing protein 81) WDR81 protein WD repeat-containing protein 81
Synonyms
Description	FUNCTION: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport . It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome . May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C . May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). .
Accessions	ENST00000631907.1 ENST00000631560.1 ENST00000419248.5 [Q562E7-6] ENST00000575206.1 ENST00000615141.4 A0A0J9YXM6 I3L1G2 ENST00000613381.4 [Q562E7-6] ENST00000468539.5 ENST00000455636.5 Q562E7 ENST00000613616.3 [Q562E7-5] C9JCF9 ENST00000611758.2 [Q562E7-3] ENST00000309182.9 [Q562E7-3] ENST00000437219.6 [Q562E7-5] Q24JR4 ENST00000634001.1 ENST00000446363.5 ENST00000632244.1 ENST00000418841.5 ENST00000632313.1 ENST00000474958.2 ENST00000632643.1 I3L3U7 E9PDG3 C9JD20 K7ELV8 ENST00000409644.6 [Q562E7-1]

WDR81 report