Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 35% ± 23% | |
| ciliated cell | 4 studies | 24% ± 7% | |
| CD4-positive, alpha-beta T cell | 3 studies | 21% ± 6% | |
| precursor B cell | 3 studies | 24% ± 3% | |
| dendritic cell | 3 studies | 28% ± 3% |
Insufficient scRNA-seq data for expression of WDR77 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1850.57 | 21 / 21 | 100% | 43.21 | 504 / 504 |
| esophagus | 100% | 1331.98 | 1445 / 1445 | 100% | 33.10 | 183 / 183 |
| intestine | 100% | 1199.05 | 966 / 966 | 100% | 50.07 | 527 / 527 |
| ovary | 100% | 880.72 | 180 / 180 | 100% | 47.35 | 430 / 430 |
| stomach | 100% | 1278.86 | 359 / 359 | 100% | 45.19 | 286 / 286 |
| lung | 100% | 1128.34 | 578 / 578 | 100% | 29.11 | 1154 / 1155 |
| prostate | 100% | 1335.55 | 245 / 245 | 100% | 28.77 | 501 / 502 |
| uterus | 100% | 1248.85 | 170 / 170 | 100% | 33.05 | 458 / 459 |
| skin | 100% | 1091.44 | 1808 / 1809 | 100% | 30.92 | 471 / 472 |
| breast | 100% | 1155.23 | 459 / 459 | 100% | 25.27 | 1114 / 1118 |
| brain | 99% | 711.71 | 2627 / 2642 | 100% | 24.69 | 705 / 705 |
| kidney | 100% | 1130.13 | 89 / 89 | 99% | 15.60 | 891 / 901 |
| thymus | 100% | 1116.28 | 652 / 653 | 99% | 19.81 | 599 / 605 |
| pancreas | 100% | 757.80 | 327 / 328 | 98% | 20.45 | 175 / 178 |
| liver | 100% | 875.34 | 226 / 226 | 96% | 14.74 | 391 / 406 |
| adrenal gland | 100% | 1637.02 | 258 / 258 | 90% | 13.70 | 208 / 230 |
| adipose | 100% | 1156.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.51 | 29 / 29 |
| muscle | 100% | 1798.26 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1672.47 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 32.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.11 | 1 / 1 |
| blood vessel | 100% | 1069.98 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1236.24 | 853 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 15.45 | 76 / 80 |
| peripheral blood | 81% | 814.57 | 752 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0000387 | Biological process | spliceosomal snRNP assembly |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0007309 | Biological process | oocyte axis specification |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0048026 | Biological process | positive regulation of mRNA splicing, via spliceosome |
| GO_0060770 | Biological process | negative regulation of epithelial cell proliferation involved in prostate gland development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060528 | Biological process | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development |
| GO_0060767 | Biological process | epithelial cell proliferation involved in prostate gland development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0034709 | Cellular component | methylosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0031465 | Cellular component | Cul4B-RING E3 ubiquitin ligase complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
| GO_0008327 | Molecular function | methyl-CpG binding |
| GO_0030374 | Molecular function | nuclear receptor coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WDR77 |
| Protein name | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) Methylosome protein WDR77 (Methylosome protein 50) (WD repeat-containing protein 77) |
| Synonyms | WD45 HKMT1069 MEP50 Nbla10071 |
| Description | FUNCTION: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones . This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage . . |
| Accessions | Q9BQA1 ENST00000235090.10 [Q9BQA1-1] ENST00000449340.1 H0Y711 |
