WDR75 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000234Biological processpositive regulation of rRNA processing
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0006364Biological processrRNA processing
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameWDR75
Protein nameWD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
WDR75 protein
WD repeat domain 75
SynonymsUTP17
DescriptionFUNCTION: Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. .

AccessionsQ05D27
F8WE20
ENST00000427960.5
F8WC81
Q8IWA0
ENST00000436347.5
ENST00000631047.1
ENST00000314761.9