WDR46 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WDR46 at tissue level.

III. Associated gene sets

GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameWDR46
Protein nameWD repeat domain 46
WD repeat-containing protein 46
WD repeat-containing protein 46 (WD repeat-containing protein BING4)
Chromosome 6 open reading frame 11 (WD repeat domain 46, isoform CRA_d) (cDNA, FLJ96697)
SynonymshCG_17524
FP221
BING4
C6orf11
DescriptionFUNCTION: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsB0UZZ8
A0A140T9L0
O15213
ENST00000450918.1
ENST00000374617.9
H0Y6G3
ENST00000432933.6
ENST00000443102.1
ENST00000444176.1
ENST00000457382.6
A0A0G2JJL1
ENST00000456332.1
ENST00000383208.8
ENST00000432609.6
ENST00000416777.1