WDR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0106004Biological processtRNA (guanine-N7)-methylation
GO_0006400Biological processtRNA modification
GO_0043527Cellular componenttRNA methyltransferase complex
GO_0106143Cellular componenttRNA (m7G46) methyltransferase complex
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0141106Molecular functiontRNA methyltransferase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR4
Protein nametRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4)
Synonyms
DescriptionFUNCTION: Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) . In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding . Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop . M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay . Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs . Also required for methylation of a specific subset of miRNAs, such as let-7 . Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 . .

AccessionsP57081
ENST00000398208.3 [P57081-1]
ENST00000330317.6 [P57081-1]