VPS52 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	21% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS52 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2854.03	1445 / 1445	100%	32.06	183 / 183
lung	100%	2553.55	578 / 578	100%	28.07	1155 / 1155
ovary	100%	3195.54	180 / 180	100%	35.59	430 / 430
stomach	100%	2503.77	359 / 359	100%	28.65	286 / 286
skin	100%	3138.94	1809 / 1809	100%	39.37	471 / 472
intestine	100%	3003.76	966 / 966	100%	29.53	525 / 527
breast	100%	3124.77	459 / 459	100%	38.12	1113 / 1118
brain	100%	2244.15	2630 / 2642	100%	44.10	702 / 705
pancreas	100%	2010.29	328 / 328	99%	22.40	176 / 178
prostate	100%	3055.18	245 / 245	98%	29.36	494 / 502
thymus	100%	4023.97	653 / 653	98%	29.63	595 / 605
kidney	100%	2483.16	89 / 89	98%	23.66	880 / 901
bladder	100%	2817.29	21 / 21	97%	25.32	491 / 504
uterus	100%	3078.69	170 / 170	97%	25.46	444 / 459
adrenal gland	100%	3625.18	258 / 258	93%	20.24	214 / 230
liver	100%	1706.92	226 / 226	93%	20.22	377 / 406
adipose	100%	2662.75	1204 / 1204	0%	0	0 / 0
muscle	100%	2816.55	803 / 803	0%	0	0 / 0
spleen	100%	3694.02	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	14.01	1 / 1
blood vessel	100%	2323.48	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	43.96	79 / 80
tonsil	0%	0	0 / 0	98%	25.84	44 / 45
heart	98%	1670.05	841 / 861	0%	0	0 / 0
peripheral blood	92%	1373.57	858 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	17.70	26 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007041	Biological process	lysosomal transport
GO_0032456	Biological process	endocytic recycling
GO_0006605	Biological process	protein targeting
GO_0048611	Biological process	embryonic ectodermal digestive tract development
GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_0006896	Biological process	Golgi to vacuole transport
GO_0015031	Biological process	protein transport
GO_0090119	Biological process	vesicle-mediated cholesterol transport
GO_0010668	Biological process	ectodermal cell differentiation
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0055037	Cellular component	recycling endosome
GO_1990745	Cellular component	EARP complex
GO_0005794	Cellular component	Golgi apparatus
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0005829	Cellular component	cytosol
GO_0010008	Cellular component	endosome membrane
GO_0000938	Cellular component	GARP complex
GO_0005515	Molecular function	protein binding
GO_0019905	Molecular function	syntaxin binding

Gene name	VPS52
Protein name	Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) Vacuolar protein sorting-associated protein 52 homolog VPS52 subunit of GARP complex (Vacuolar protein sorting-associated protein 52 homolog)
Synonyms	SACM2L RP5-1033B10.17-001
Description	FUNCTION: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD . Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane . .
Accessions	ENST00000476725.6 A0A0G2JIG2 ENST00000462479.1 ENST00000478392.5 ENST00000443860.2 [Q8N1B4-1] ENST00000383210.4 [Q8N1B4-1] ENST00000445902.3 [Q8N1B4-1] Q8N1B4 ENST00000448042.2 [Q8N1B4-1] ENST00000421357.5 ENST00000497240.5 Q4VXZ2 E9PI03 ENST00000482399.5 ENST00000428608.2 [Q8N1B4-1] ENST00000461476.5 ENST00000441058.2 [Q8N1B4-1]

VPS52 report