VPS33B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of VPS33B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS33B at tissue level.

III. Associated gene sets

GO_0046907Biological processintracellular transport
GO_0032963Biological processcollagen metabolic process
GO_0032400Biological processmelanosome localization
GO_0061025Biological processmembrane fusion
GO_0006886Biological processintracellular protein transport
GO_0017185Biological processpeptidyl-lysine hydroxylation
GO_0090330Biological processregulation of platelet aggregation
GO_0035855Biological processmegakaryocyte development
GO_0016192Biological processvesicle-mediated transport
GO_0070889Biological processplatelet alpha granule organization
GO_0090385Biological processphagosome-lysosome fusion
GO_0008333Biological processendosome to lysosome transport
GO_0032418Biological processlysosome localization
GO_0007032Biological processendosome organization
GO_0043589Biological processskin morphogenesis
GO_0015031Biological processprotein transport
GO_0030199Biological processcollagen fibril organization
GO_0097352Biological processautophagosome maturation
GO_0031091Cellular componentplatelet alpha granule
GO_0033263Cellular componentCORVET complex
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0055037Cellular componentrecycling endosome
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0099023Cellular componentvesicle tethering complex
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS33B
Protein nameVPS33B late endosome and lysosome associated
Vacuolar protein sorting 33-like protein B isoform 3
Vacuolar protein sorting-associated protein 33B (hVPS33B)
Vacuolar protein sorting 33-like protein B isoform 2
Vacuolar protein sorting-associated protein 33B
SynonymshCG_32582
DescriptionFUNCTION: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen . Mediates phagolysosomal fusion in macrophages . Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity . Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). .

AccessionsQ9H267
ENST00000333371.8 [Q9H267-1]
A0A0S2Z577
A0A0S2Z555
A0A0S2Z589
ENST00000535906.1
G3V3F9
F5H008
ENST00000574755.5