VPS26C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0032456Biological processendocytic recycling
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameVPS26C
Protein nameVacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A)
VPS26 endosomal protein sorting factor C
VPS26 endosomal protein sorting factor C (cDNA FLJ53689, highly similar to Down syndrome critical region protein 3)
SynonymsDSCRA
DCRA
DSCR3
DescriptionFUNCTION: Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) . The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes . In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling . .; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. .

AccessionsENST00000309117.11 [O14972-1]
ENST00000476950.5 [O14972-2]
A8MY26
ENST00000399001.5
ENST00000398998.1
A8MTY9
O14972