VASH2 | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	3 studies	23% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of VASH2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	98%	264.93	449 / 459	84%	4.50	936 / 1118
prostate	100%	313.02	245 / 245	72%	1.66	359 / 502
lung	99%	209.95	573 / 578	56%	1.82	648 / 1155
uterus	100%	272.35	170 / 170	51%	3.91	234 / 459
bladder	100%	319.57	21 / 21	50%	2.01	251 / 504
ovary	87%	152.79	156 / 180	61%	1.94	264 / 430
esophagus	98%	273.91	1417 / 1445	49%	2.06	90 / 183
brain	94%	127.74	2490 / 2642	50%	1.43	351 / 705
stomach	86%	82.01	307 / 359	50%	1.20	144 / 286
intestine	90%	127.16	869 / 966	39%	0.79	207 / 527
thymus	95%	97.92	621 / 653	19%	1.00	113 / 605
spleen	100%	155.30	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.78	1 / 1
adipose	96%	246.69	1160 / 1204	0%	0	0 / 0
kidney	79%	66.92	70 / 89	17%	0.37	156 / 901
heart	83%	132.76	713 / 861	0%	0	0 / 0
pancreas	25%	15.64	81 / 328	54%	1.19	97 / 178
skin	67%	66.65	1217 / 1809	11%	0.54	54 / 472
lymph node	0%	0	0 / 0	52%	1.83	15 / 29
blood vessel	51%	49.58	684 / 1335	0%	0	0 / 0
liver	23%	13.24	53 / 226	26%	0.57	107 / 406
adrenal gland	42%	27.47	108 / 258	6%	0.15	14 / 230
tonsil	0%	0	0 / 0	44%	1.37	20 / 45
muscle	36%	29.11	286 / 803	0%	0	0 / 0
peripheral blood	22%	802.88	209 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0140253	Biological process	cell-cell fusion
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0061564	Biological process	axon development
GO_0060716	Biological process	labyrinthine layer blood vessel development
GO_0006508	Biological process	proteolysis
GO_0045765	Biological process	regulation of angiogenesis
GO_0000768	Biological process	syncytium formation by plasma membrane fusion
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0005737	Cellular component	cytoplasm
GO_0106423	Molecular function	tubulin-tyrosine carboxypeptidase
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0008017	Molecular function	microtubule binding
GO_0004181	Molecular function	metallocarboxypeptidase activity

Gene name	VASH2
Protein name	Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) Vasohibin 2
Synonyms	VASHL
Description	FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function . Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning . Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis . Plays a role in axon formation . .
Accessions	Q86V25 ENST00000366968.8 [Q86V25-2] C9JY36 ENST00000366964.7 [Q86V25-4] ENST00000366967.6 [Q86V25-6] ENST00000490792.1 ENST00000517399.3 [Q86V25-1] ENST00000366965.6 [Q86V25-5] ENST00000366966.6 [Q86V25-2]

VASH2 report