UVSSA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0009411Biological processresponse to UV
GO_0006283Biological processtranscription-coupled nucleotide-excision repair
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUVSSA
Protein nameUV stimulated scaffold protein A
UV-stimulated scaffold protein A
SynonymsKIAA1530
DescriptionFUNCTION: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes . Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites . Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome . Also facilitates transfer of TFIIH to RNA polymerase II . Not involved in processing oxidative damage . .

AccessionsENST00000389851.10 [Q2YD98-1]
Q2YD98
ENST00000512728.5 [Q2YD98-2]
A0A7I2V3L2
H0Y924
ENST00000507531.5 [Q2YD98-1]
ENST00000677428.1
A0A7I2V4K1
A0A7I2V554
ENST00000511216.6 [Q2YD98-1]
ENST00000679192.1 [Q2YD98-1]
ENST00000679242.1
ENST00000677286.1 [Q2YD98-1]
ENST00000678994.1
ENST00000503548.1