USPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009301Biological processsnRNA transcription
GO_0016926Biological processprotein desumoylation
GO_0008283Biological processcell population proliferation
GO_0030576Biological processCajal body organization
GO_0006508Biological processproteolysis
GO_0015030Cellular componentCajal body
GO_0005615Cellular componentextracellular space
GO_0032183Molecular functionSUMO binding
GO_0016929Molecular functiondeSUMOylase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUSPL1
Protein nameAlternative protein USPL1
SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1)
SynonymsD13S106
C13orf22
DescriptionFUNCTION: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms . Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies . Is a component of complexes that can bind to U snRNA genes . .

AccessionsL8ECC7
ENST00000614860.1 [Q5W0Q7-2]
Q5W0Q7
ENST00000255304.9 [Q5W0Q7-1]