USP46 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	5 studies	21% ± 5%	Explore
astrocyte	5 studies	26% ± 9%	Explore
retinal bipolar neuron	4 studies	29% ± 8%	Explore
epithelial cell	4 studies	34% ± 9%	Explore
basal cell	4 studies	26% ± 8%	Explore
ciliated cell	4 studies	20% ± 3%	Explore
glutamatergic neuron	4 studies	43% ± 17%	Explore
cardiac muscle cell	3 studies	16% ± 1%	Explore
rod bipolar cell	3 studies	24% ± 9%	Explore
GABAergic neuron	3 studies	38% ± 2%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 7%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	34% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5188.31	2642 / 2642	100%	29.78	704 / 705
prostate	100%	1384.82	245 / 245	99%	9.78	499 / 502
esophagus	99%	1602.83	1434 / 1445	100%	9.28	183 / 183
ovary	100%	2454.90	180 / 180	98%	6.87	423 / 430
breast	98%	1121.71	448 / 459	100%	12.85	1114 / 1118
uterus	99%	1529.05	169 / 170	98%	9.48	449 / 459
bladder	100%	1282.24	21 / 21	97%	9.35	490 / 504
thymus	100%	1464.10	651 / 653	98%	9.00	590 / 605
skin	100%	1909.83	1803 / 1809	95%	9.11	448 / 472
intestine	98%	953.05	951 / 966	95%	5.60	503 / 527
stomach	99%	1148.27	356 / 359	94%	5.76	270 / 286
adrenal gland	100%	1780.77	257 / 258	91%	6.48	210 / 230
kidney	100%	1624.22	89 / 89	88%	5.12	797 / 901
pancreas	91%	809.82	298 / 328	97%	6.52	173 / 178
lung	88%	885.63	509 / 578	99%	9.26	1142 / 1155
tonsil	0%	0	0 / 0	100%	9.71	45 / 45
ureter	0%	0	0 / 0	100%	6.43	1 / 1
muscle	97%	1318.17	777 / 803	0%	0	0 / 0
blood vessel	96%	1162.66	1286 / 1335	0%	0	0 / 0
adipose	96%	921.40	1157 / 1204	0%	0	0 / 0
spleen	95%	805.15	230 / 241	0%	0	0 / 0
liver	40%	245.67	91 / 226	55%	2.20	222 / 406
heart	94%	2160.00	809 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	5.51	73 / 80
lymph node	0%	0	0 / 0	69%	3.14	20 / 29
peripheral blood	19%	371.70	179 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0001662	Biological process	behavioral fear response
GO_0008343	Biological process	adult feeding behavior
GO_0016579	Biological process	protein deubiquitination
GO_0060013	Biological process	righting reflex
GO_0006508	Biological process	proteolysis
GO_0048149	Biological process	behavioral response to ethanol
GO_0032228	Biological process	regulation of synaptic transmission, GABAergic
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0046872	Molecular function	metal ion binding

Gene name	USP46
Protein name	Ubiquitin specific peptidase 46 Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) Alternative protein USP46
Synonyms
Description	FUNCTION: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity . Not involved in deubiquitination of monoubiquitinated FANCD2 . .
Accessions	ENST00000503060.5 ENST00000451218.6 H7BZK6 D6R9Z4 ENST00000508499.5 [P62068-3] ENST00000514536.5 P62068 ENST00000441222.8 [P62068-1] L8ECJ9

USP46 report