USP45 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	7 studies	23% ± 4%	Explore
astrocyte	7 studies	33% ± 15%	Explore
adipocyte	6 studies	21% ± 4%	Explore
glutamatergic neuron	4 studies	53% ± 22%	Explore
GABAergic neuron	4 studies	44% ± 18%	Explore
oligodendrocyte precursor cell	4 studies	30% ± 10%	Explore
oligodendrocyte	4 studies	28% ± 6%	Explore
glycinergic amacrine cell	3 studies	24% ± 8%	Explore
transit amplifying cell	3 studies	20% ± 6%	Explore
interneuron	3 studies	41% ± 22%	Explore

Name	Number of supported studies	Average coverage
brain	5 studies	41% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	817.96	1445 / 1445	100%	6.48	183 / 183
prostate	100%	955.58	245 / 245	100%	5.72	501 / 502
lung	100%	771.68	576 / 578	100%	4.63	1154 / 1155
brain	99%	1003.69	2628 / 2642	100%	4.09	705 / 705
breast	100%	993.72	459 / 459	99%	5.01	1109 / 1118
thymus	100%	1032.99	653 / 653	98%	3.77	595 / 605
stomach	100%	709.99	359 / 359	98%	5.36	281 / 286
intestine	100%	1045.89	966 / 966	98%	4.86	517 / 527
bladder	100%	918.38	21 / 21	98%	3.87	494 / 504
uterus	100%	1104.93	170 / 170	98%	3.89	448 / 459
kidney	100%	735.35	89 / 89	98%	4.52	879 / 901
pancreas	100%	535.56	327 / 328	98%	3.60	174 / 178
ovary	100%	1061.27	180 / 180	97%	3.27	419 / 430
adrenal gland	100%	631.26	258 / 258	96%	3.18	220 / 230
skin	100%	953.53	1807 / 1809	88%	3.51	415 / 472
liver	100%	436.18	226 / 226	71%	1.48	288 / 406
adipose	100%	957.00	1204 / 1204	0%	0	0 / 0
spleen	100%	939.33	241 / 241	0%	0	0 / 0
muscle	100%	674.45	802 / 803	0%	0	0 / 0
blood vessel	100%	821.64	1333 / 1335	0%	0	0 / 0
heart	98%	512.05	844 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	3.07	44 / 45
lymph node	0%	0	0 / 0	90%	3.17	26 / 29
eye	0%	0	0 / 0	60%	1.72	48 / 80
peripheral blood	32%	431.66	297 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045494	Biological process	photoreceptor cell maintenance
GO_0016579	Biological process	protein deubiquitination
GO_0006281	Biological process	DNA repair
GO_0070911	Biological process	global genome nucleotide-excision repair
GO_0006508	Biological process	proteolysis
GO_0016477	Biological process	cell migration
GO_0003407	Biological process	neural retina development
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0001917	Cellular component	photoreceptor inner segment
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

Gene name	USP45
Protein name	Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Ubiquitin specific peptidase 45 ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Synonyms	hCG_17265
Description	FUNCTION: Catalyzes the deubiquitination of SPDL1 . Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites . May be involved in the maintenance of photoreceptor function . May play a role in normal retinal development (By similarity). Plays a role in cell migration . . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .
Accessions	Q70EL2 ENST00000496090.6 E2QRF0 ENST00000511403.5 ENST00000327681.10 [Q70EL2-1] ENST00000500704.7 [Q70EL2-1] ENST00000507717.5 ENST00000369233.6 H0YA21 H0Y986 H0Y8J5 D6RC01 D6RE98 ENST00000506871.5 H0Y8Q0 ENST00000508908.1 ENST00000329966.10 ENST00000472914.6 D6RBV3 ENST00000496518.6

USP45 report