USP38 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016579Biological processprotein deubiquitination
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140311Molecular functionprotein sequestering activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP38
Protein nameUbiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38)
Ubiquitin specific peptidase 38
SynonymsKIAA1891
DescriptionFUNCTION: Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response . Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation . Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells . Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 . Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage . Acts also as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'-linked ubiquitin chains to lower its histone deacetylase activity . Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation . Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E . Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation . .

AccessionsA0A804HIS3
A0A804HIT0
ENST00000683224.1
ENST00000307017.9 [Q8NB14-1]
ENST00000682469.1
A0A804HL80
Q8NB14
ENST00000511739.1
ENST00000510377.5 [Q8NB14-2]
ENST00000684586.1
H0Y9H5