USP37 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0051301Biological processcell division
GO_0035871Biological processprotein K11-linked deubiquitination
GO_0006508Biological processproteolysis
GO_0006275Biological processregulation of DNA replication
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0016579Biological processprotein deubiquitination
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP37
Protein nameUbiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsKIAA1594
DescriptionFUNCTION: Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response . Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) . Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 . Plays also an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability . Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM . Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM . Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI . Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination . .

AccessionsENST00000415516.5 [Q86T82-2]
ENST00000418019.5 [Q86T82-1]
Q86T82
ENST00000258399.8 [Q86T82-1]
ENST00000454775.5 [Q86T82-1]
Q86W68
ENST00000338465.5