USP30 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	32% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1441.09	2640 / 2642	100%	22.57	705 / 705
prostate	100%	1060.27	245 / 245	100%	14.14	501 / 502
stomach	100%	776.36	358 / 359	100%	11.06	286 / 286
adrenal gland	100%	1734.06	258 / 258	100%	19.93	229 / 230
ovary	100%	1452.62	180 / 180	100%	12.60	428 / 430
liver	100%	1224.15	226 / 226	100%	12.61	404 / 406
breast	100%	1323.11	459 / 459	99%	16.02	1112 / 1118
esophagus	100%	837.28	1445 / 1445	99%	9.29	182 / 183
kidney	100%	847.91	89 / 89	99%	13.05	896 / 901
bladder	100%	1007.67	21 / 21	99%	9.99	501 / 504
thymus	100%	1093.84	653 / 653	99%	14.12	601 / 605
lung	100%	957.90	577 / 578	99%	9.70	1149 / 1155
intestine	100%	1206.29	966 / 966	99%	11.21	523 / 527
pancreas	100%	772.88	328 / 328	99%	9.26	176 / 178
uterus	100%	1315.52	170 / 170	99%	9.71	453 / 459
skin	100%	1381.98	1809 / 1809	98%	11.37	464 / 472
adipose	100%	1241.36	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	6.72	29 / 29
spleen	100%	800.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	8.71	45 / 45
ureter	0%	0	0 / 0	100%	5.05	1 / 1
blood vessel	100%	1005.44	1334 / 1335	0%	0	0 / 0
muscle	100%	935.87	802 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	99%	11.24	79 / 80
heart	96%	669.32	829 / 861	0%	0	0 / 0
peripheral blood	70%	316.94	651 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0000422	Biological process	autophagy of mitochondrion
GO_1901525	Biological process	negative regulation of mitophagy
GO_0000425	Biological process	pexophagy
GO_0008053	Biological process	mitochondrial fusion
GO_0035871	Biological process	protein K11-linked deubiquitination
GO_0006508	Biological process	proteolysis
GO_0044313	Biological process	protein K6-linked deubiquitination
GO_0016579	Biological process	protein deubiquitination
GO_0005778	Cellular component	peroxisomal membrane
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005829	Cellular component	cytosol
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0101005	Molecular function	deubiquitinase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

Gene name	USP30
Protein name	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Ubiquitin specific peptidase 30 Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30)
Synonyms
Description	FUNCTION: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy . Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling . Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' . Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .
Accessions	ENST00000392784.6 ENST00000539121.1 ENST00000377883.7 ENST00000536393.5 S4R3D1 Q70CQ3 F5GXG2 ENST00000470117.2 F5H8D3 ENST00000536723.5 F5H3L3 ENST00000257548.10 S4R354 B3KUS5

USP30 report