USP27X | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP27X at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	993.23	2636 / 2642	100%	11.99	702 / 705
prostate	100%	351.36	245 / 245	99%	6.14	497 / 502
breast	99%	220.45	456 / 459	99%	7.56	1104 / 1118
skin	100%	257.38	1808 / 1809	97%	8.22	458 / 472
thymus	99%	212.46	646 / 653	98%	9.05	592 / 605
bladder	100%	367.00	21 / 21	94%	5.60	475 / 504
uterus	100%	478.78	170 / 170	94%	6.57	430 / 459
ovary	100%	445.73	180 / 180	93%	6.12	400 / 430
kidney	100%	203.55	89 / 89	93%	6.61	836 / 901
lung	97%	251.23	562 / 578	95%	8.52	1100 / 1155
adrenal gland	94%	257.55	242 / 258	97%	16.42	224 / 230
intestine	99%	322.23	961 / 966	91%	5.31	481 / 527
stomach	98%	247.73	353 / 359	91%	5.44	260 / 286
pancreas	91%	141.38	297 / 328	95%	7.34	169 / 178
esophagus	98%	277.26	1417 / 1445	87%	4.13	159 / 183
liver	51%	66.96	116 / 226	64%	3.50	258 / 406
spleen	100%	216.52	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.29	1 / 1
blood vessel	100%	368.57	1332 / 1335	0%	0	0 / 0
adipose	100%	204.52	1198 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	7.80	79 / 80
tonsil	0%	0	0 / 0	93%	5.13	42 / 45
muscle	86%	139.11	694 / 803	0%	0	0 / 0
heart	86%	138.93	743 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	2.63	22 / 29
peripheral blood	34%	46.57	317 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0051607	Biological process	defense response to virus
GO_0071108	Biological process	protein K48-linked deubiquitination
GO_0070536	Biological process	protein K63-linked deubiquitination
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0006508	Biological process	proteolysis
GO_0050821	Biological process	protein stabilization
GO_0060340	Biological process	positive regulation of type I interferon-mediated signaling pathway
GO_0045087	Biological process	innate immune response
GO_0016579	Biological process	protein deubiquitination
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_1990380	Molecular function	K48-linked deubiquitinase activity
GO_0061578	Molecular function	K63-linked deubiquitinase activity

Gene name	USP27X
Protein name	Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)
Synonyms	USP27 USP22L
Description	FUNCTION: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI . Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling . Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 . Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization . Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity). .
Accessions	A6NNY8 ENST00000621775.2

USP27X report