USP19 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP19 at tissue level.

III. Associated gene sets

GO_1904292Biological processregulation of ERAD pathway
GO_0048642Biological processnegative regulation of skeletal muscle tissue development
GO_0031647Biological processregulation of protein stability
GO_0016579Biological processprotein deubiquitination
GO_1900037Biological processregulation of cellular response to hypoxia
GO_0050821Biological processprotein stabilization
GO_0090068Biological processpositive regulation of cell cycle process
GO_0036503Biological processERAD pathway
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0005829Cellular componentcytosol
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0046872Molecular functionmetal ion binding
GO_0051879Molecular functionHsp90 protein binding

IV. Literature review

[source]
Gene nameUSP19
Protein nameUbiquitin carboxyl-terminal hydrolase 19
Ubiquitin specific peptidase 19
USP19 protein
Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)
SynonymsZMYND9
KIAA0891
DescriptionFUNCTION: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. .

AccessionsENST00000398896
ENST00000453664.5 [O94966-7]
A0A8I5KT08
ENST00000693111.1
A5PL36
E7ESU0
A0A8I5KRW4
ENST00000398888.6 [O94966-1]
ENST00000417901.6 [O94966-6]
ENST00000398896.6 [O94966-4]
ENST00000434032.6 [O94966-5]
ENST00000465902.2
ENST00000698200.1
A0A590UK03
O94966
A0A8I5KXK1
ENST00000689715.1
A0A8V8TN96
ENST00000692912.1
ENST00000306026.6
A0A0A0MR08
ENST00000691288.1
A0A8I5KV50