USP18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP18 at tissue level.

III. Associated gene sets

GO_0035634Biological processresponse to stilbenoid
GO_0016579Biological processprotein deubiquitination
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0050727Biological processregulation of inflammatory response
GO_0006508Biological processproteolysis
GO_0140374Biological processantiviral innate immune response
GO_0009617Biological processresponse to bacterium
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019785Molecular functionISG15-specific peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameUSP18
Protein nameUbl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)
Ubiquitin specific peptidase 18
SynonymsISG43
DescriptionFUNCTION: Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells . Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions . In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation . Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1 . Involved also in the negative regulation of the inflammatory response triggered by type I interferon . Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway . .; FUNCTION: [Isoform 2]: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins . .

AccessionsA0A8V8TMN0
Q9UMW8
ENST00000215794.8 [Q9UMW8-1]
ENST00000699060.1