Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| natural killer cell | 9 studies | 18% ± 3% | |
| CD16-positive, CD56-dim natural killer cell, human | 8 studies | 20% ± 4% | |
| classical monocyte | 4 studies | 24% ± 7% | |
| non-classical monocyte | 3 studies | 26% ± 3% | |
| epithelial cell | 3 studies | 24% ± 4% | |
| dendritic cell | 3 studies | 24% ± 3% | |
| gamma-delta T cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of USB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2619.02 | 1445 / 1445 | 100% | 33.19 | 183 / 183 |
| stomach | 100% | 1979.70 | 359 / 359 | 100% | 21.65 | 286 / 286 |
| thymus | 100% | 2988.18 | 653 / 653 | 100% | 28.55 | 605 / 605 |
| uterus | 100% | 2281.34 | 170 / 170 | 100% | 27.21 | 459 / 459 |
| skin | 100% | 2075.57 | 1806 / 1809 | 100% | 26.82 | 472 / 472 |
| intestine | 100% | 2629.22 | 966 / 966 | 100% | 21.33 | 526 / 527 |
| brain | 100% | 1889.02 | 2632 / 2642 | 100% | 20.82 | 705 / 705 |
| ovary | 100% | 1536.84 | 180 / 180 | 100% | 17.48 | 428 / 430 |
| lung | 100% | 2869.45 | 578 / 578 | 99% | 28.89 | 1148 / 1155 |
| bladder | 100% | 2983.19 | 21 / 21 | 99% | 28.17 | 500 / 504 |
| breast | 100% | 1988.34 | 459 / 459 | 99% | 18.34 | 1107 / 1118 |
| liver | 100% | 2152.32 | 226 / 226 | 99% | 12.92 | 402 / 406 |
| prostate | 100% | 2471.56 | 245 / 245 | 99% | 13.65 | 497 / 502 |
| kidney | 100% | 1934.58 | 89 / 89 | 99% | 15.03 | 892 / 901 |
| adrenal gland | 100% | 3270.24 | 258 / 258 | 99% | 22.16 | 227 / 230 |
| pancreas | 100% | 1283.29 | 327 / 328 | 98% | 22.82 | 175 / 178 |
| adipose | 100% | 2115.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 25.25 | 29 / 29 |
| peripheral blood | 100% | 8245.58 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3489.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.39 | 1 / 1 |
| blood vessel | 100% | 2270.58 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 13.77 | 79 / 80 |
| heart | 98% | 1979.69 | 848 / 861 | 0% | 0 | 0 / 0 |
| muscle | 95% | 1065.65 | 765 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008380 | Biological process | RNA splicing |
| GO_0034472 | Biological process | snRNA 3'-end processing |
| GO_0034477 | Biological process | U6 snRNA 3'-end processing |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0045171 | Cellular component | intercellular bridge |
| GO_0005634 | Cellular component | nucleus |
| GO_0000175 | Molecular function | 3'-5'-RNA exonuclease activity |
| GO_1990838 | Molecular function | poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends |
| GO_0016829 | Molecular function | lyase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | USB1 |
| Protein name | U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) U6 snRNA phosphodiesterase (EC 3.1.4.-) U6 snRNA phosphodiesterase 1 (3'-5' RNA exonuclease USB1) U6 snRNA biogenesis phosphodiesterase 1 |
| Synonyms | Mpn1 C16orf57 |
| Description | FUNCTION: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate . Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation . In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 . . FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. . FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. . FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. . |
| Accessions | ENST00000561568.6 A0A8V8TN78 ENST00000562534.5 A0A8V8TLS7 ENST00000698445.1 ENST00000698444.1 A0A8V8TLQ0 Q9BQ65 ENST00000698446.1 B4DPS2 ENST00000565662.6 ENST00000539737.6 [Q9BQ65-2] ENST00000219281.8 [Q9BQ65-1] ENST00000564387.5 H3BTT8 ENST00000569252.5 H3BTS1 ENST00000423271.8 [Q9BQ65-3] A0A8V8TM93 A0A8V8TNL4 H3BNM8 ENST00000561743.5 ENST00000698510.1 H3BN52 ENST00000698447.1 A0A8V8TM89 ENST00000563149.2 |
