Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 9 studies | 20% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 20% ± 4% | |
endothelial cell | 5 studies | 22% ± 8% | |
epithelial cell | 5 studies | 34% ± 15% | |
erythrocyte | 5 studies | 44% ± 15% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 18% ± 2% | |
erythroblast | 4 studies | 45% ± 25% | |
astrocyte | 4 studies | 23% ± 3% | |
glutamatergic neuron | 4 studies | 40% ± 21% | |
oligodendrocyte | 4 studies | 21% ± 2% | |
hematopoietic precursor cell | 3 studies | 30% ± 9% | |
conventional dendritic cell | 3 studies | 27% ± 9% | |
non-classical monocyte | 3 studies | 23% ± 7% | |
retinal ganglion cell | 3 studies | 53% ± 26% | |
amacrine cell | 3 studies | 33% ± 12% | |
retina horizontal cell | 3 studies | 28% ± 13% | |
fibroblast | 3 studies | 24% ± 7% | |
ciliated cell | 3 studies | 21% ± 4% | |
GABAergic neuron | 3 studies | 37% ± 15% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 35% ± 23% | |
basal cell | 3 studies | 29% ± 9% | |
interneuron | 3 studies | 30% ± 14% | |
oligodendrocyte precursor cell | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1778.65 | 1445 / 1445 | 100% | 8.55 | 183 / 183 |
prostate | 100% | 2057.99 | 245 / 245 | 100% | 14.04 | 502 / 502 |
skin | 100% | 2062.55 | 1809 / 1809 | 100% | 13.32 | 472 / 472 |
stomach | 100% | 1504.31 | 359 / 359 | 100% | 10.34 | 286 / 286 |
thymus | 100% | 2355.81 | 653 / 653 | 100% | 16.09 | 605 / 605 |
brain | 100% | 4146.90 | 2641 / 2642 | 100% | 15.66 | 705 / 705 |
kidney | 100% | 2290.33 | 89 / 89 | 100% | 12.82 | 900 / 901 |
breast | 100% | 1929.23 | 459 / 459 | 100% | 15.80 | 1116 / 1118 |
liver | 100% | 1937.19 | 226 / 226 | 100% | 12.29 | 405 / 406 |
intestine | 100% | 1782.42 | 966 / 966 | 100% | 11.02 | 525 / 527 |
uterus | 99% | 1449.27 | 169 / 170 | 100% | 12.52 | 457 / 459 |
ovary | 99% | 1615.29 | 178 / 180 | 100% | 15.82 | 430 / 430 |
adrenal gland | 100% | 2431.27 | 258 / 258 | 99% | 13.41 | 227 / 230 |
bladder | 100% | 1880.29 | 21 / 21 | 99% | 10.56 | 497 / 504 |
pancreas | 99% | 1198.49 | 326 / 328 | 99% | 10.79 | 176 / 178 |
lung | 98% | 1492.11 | 566 / 578 | 100% | 12.34 | 1155 / 1155 |
adipose | 100% | 1893.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 19.63 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.63 | 29 / 29 |
muscle | 100% | 2902.13 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1986.97 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 9.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.37 | 1 / 1 |
blood vessel | 99% | 1432.26 | 1327 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 2824.14 | 848 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 88% | 1232.52 | 822 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006782 | Biological process | protoporphyrinogen IX biosynthetic process |
GO_0070541 | Biological process | response to platinum ion |
GO_0006780 | Biological process | uroporphyrinogen III biosynthetic process |
GO_0006783 | Biological process | heme biosynthetic process |
GO_0006784 | Biological process | heme A biosynthetic process |
GO_0071418 | Biological process | cellular response to amine stimulus |
GO_0071243 | Biological process | cellular response to arsenic-containing substance |
GO_0048034 | Biological process | heme O biosynthetic process |
GO_0006785 | Biological process | heme B biosynthetic process |
GO_0005829 | Cellular component | cytosol |
GO_0005739 | Cellular component | mitochondrion |
GO_0004852 | Molecular function | uroporphyrinogen-III synthase activity |
GO_0005542 | Molecular function | folic acid binding |
Gene name | UROS |
Protein name | Uroporphyrinogen III synthase uroporphyrinogen-III synthase (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) UROS protein |
Synonyms | hCG_1727047 |
Description | FUNCTION: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins . Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). . |
Accessions | A0A3B3ITJ2 A0A0S2Z4T8 Q5T3L9 A0A087WZB7 Q9BT54 A0A3B3ISM6 ENST00000622016.4 ENST00000464267.1 ENST00000465577.6 ENST00000368778.7 A0A3B3ISX6 A0A3B3IS33 ENST00000462490.5 A0A087X021 ENST00000649536.1 ENST00000368797.10 P10746 ENST00000368786.5 ENST00000420761.5 A0A087WUV7 ENST00000649275.1 ENST00000650524.1 Q5T3L8 ENST00000648427.1 Q5T3L7 A0A3B3IS76 A0A3B3IU75 ENST00000368774.1 A0A3B3IUC8 A0A0S2Z5C5 ENST00000648119.1 A0A3B3ISL9 ENST00000616800.4 ENST00000650185.1 ENST00000650587.1 |