UROS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006782Biological processprotoporphyrinogen IX biosynthetic process
GO_0070541Biological processresponse to platinum ion
GO_0006780Biological processuroporphyrinogen III biosynthetic process
GO_0006783Biological processheme biosynthetic process
GO_0006784Biological processheme A biosynthetic process
GO_0071418Biological processcellular response to amine stimulus
GO_0071243Biological processcellular response to arsenic-containing substance
GO_0048034Biological processheme O biosynthetic process
GO_0006785Biological processheme B biosynthetic process
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0004852Molecular functionuroporphyrinogen-III synthase activity
GO_0005542Molecular functionfolic acid binding

IV. Literature review

[source]
Gene nameUROS
Protein nameUroporphyrinogen III synthase
uroporphyrinogen-III synthase (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase)
Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase)
UROS protein
SynonymshCG_1727047
DescriptionFUNCTION: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins . Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). .

AccessionsA0A3B3ITJ2
A0A0S2Z4T8
Q5T3L9
A0A087WZB7
Q9BT54
A0A3B3ISM6
ENST00000622016.4
ENST00000464267.1
ENST00000465577.6
ENST00000368778.7
A0A3B3ISX6
A0A3B3IS33
ENST00000462490.5
A0A087X021
ENST00000649536.1
ENST00000368797.10
P10746
ENST00000368786.5
ENST00000420761.5
A0A087WUV7
ENST00000649275.1
ENST00000650524.1
Q5T3L8
ENST00000648427.1
Q5T3L7
A0A3B3IS76
A0A3B3IU75
ENST00000368774.1
A0A3B3IUC8
A0A0S2Z5C5
ENST00000648119.1
A0A3B3ISL9
ENST00000616800.4
ENST00000650185.1
ENST00000650587.1