UNC80 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0055080Biological processmonoatomic cation homeostasis
GO_0030424Cellular componentaxon
GO_0034703Cellular componentcation channel complex
GO_0005886Cellular componentplasma membrane
GO_0005261Molecular functionmonoatomic cation channel activity

IV. Literature review

[source]
Gene nameUNC80
Protein nameProtein unc-80 homolog
Unc-80 homolog, NALCN channel complex subunit
SynonymsKIAA1843
C2orf21
DescriptionFUNCTION: Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular Ca(2+) (By similarity). .

AccessionsA0A669KAW8
ENST00000439458.5 [Q8N2C7-1]
Q8N2C7
ENST00000673920.1
ENST00000673951.1
ENST00000333907.3
A0A669KBC5
ENST00000272845.10 [Q8N2C7-7]
H3BLU5