UNC13A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099011Biological processneuronal dense core vesicle exocytosis
GO_0007269Biological processneurotransmitter secretion
GO_0061789Biological processdense core granule priming
GO_1903861Biological processpositive regulation of dendrite extension
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0016081Biological processsynaptic vesicle docking
GO_0099525Biological processpresynaptic dense core vesicle exocytosis
GO_0030154Biological processcell differentiation
GO_0016082Biological processsynaptic vesicle priming
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043195Cellular componentterminal bouton
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0048786Cellular componentpresynaptic active zone
GO_0098831Cellular componentpresynaptic active zone cytoplasmic component
GO_0005543Molecular functionphospholipid binding
GO_0017075Molecular functionsyntaxin-1 binding
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene nameUNC13A
Protein nameUnc-13 homolog A
Protein unc-13 homolog A (Munc13-1)
SynonymsKIAA1032
DescriptionFUNCTION: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes . .

AccessionsENST00000551649.5
F8W059
ENST00000552293.5
ENST00000519716.7
Q9UPW8
F8W0P6
F8VZH8
ENST00000550896.1