UGT2B28 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT2B28 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT2B28 at tissue level.

III. Associated gene sets

GO_0052697Biological processxenobiotic glucuronidation
GO_0008202Biological processsteroid metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0008210Biological processestrogen metabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005640Cellular componentnuclear outer membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015020Molecular functionglucuronosyltransferase activity

IV. Literature review

[source]
Gene nameUGT2B28
Protein nameUDP-glucuronosyltransferase 2B28 (UDPGT 2B28) (UGT2B28) (EC 2.4.1.17)
Synonyms
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) . Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption . Displays glucuronidation activity toward the phenolic compounds eugenol . .; FUNCTION: [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity. .

AccessionsQ9BY64
ENST00000335568.10 [Q9BY64-1]
ENST00000511240.1 [Q9BY64-2]