UGT1A9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A9 at tissue level.

III. Associated gene sets

GO_0052697Biological processxenobiotic glucuronidation
GO_0051552Biological processflavone metabolic process
GO_0001889Biological processliver development
GO_0006805Biological processxenobiotic metabolic process
GO_0052696Biological processflavonoid glucuronidation
GO_0042573Biological processretinoic acid metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0046982Molecular functionprotein heterodimerization activity
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameUGT1A9
Protein nameUDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4)
UDP-glucuronosyltransferase variant (EC 2.4.1.17)
UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A9
UDP-glucuronosyltransferase (EC 2.4.1.17)
SynonymsGNT1
hCG_2039726
UGT1
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone . Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II . Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan . Also metabolizes mycophenolate, an immunosuppressive agent . .; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. .

AccessionsQ4R0Z7
Q5DSZ5
O60656
A9UKF4
Q53E75
A9UKF7
Q4R0Z6
Q330M4
ENST00000354728.5 [O60656-1]