UGT1A8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A8 at tissue level.

III. Associated gene sets

GO_0009804Biological processcoumarin metabolic process
GO_0052697Biological processxenobiotic glucuronidation
GO_0001889Biological processliver development
GO_0042573Biological processretinoic acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0045939Biological processnegative regulation of steroid metabolic process
GO_0045922Biological processnegative regulation of fatty acid metabolic process
GO_0051552Biological processflavone metabolic process
GO_0052696Biological processflavonoid glucuronidation
GO_0052695Biological processcellular glucuronidation
GO_0008202Biological processsteroid metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004857Molecular functionenzyme inhibitor activity
GO_0005504Molecular functionfatty acid binding
GO_0001972Molecular functionretinoic acid binding
GO_0005496Molecular functionsteroid binding
GO_0046982Molecular functionprotein heterodimerization activity

IV. Literature review

[source]
Gene nameUGT1A8
Protein nameUDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H)
UDP-glucuronosyltransferase 1A8
UDP-glucuronosyltransferase (EC 2.4.1.17)
SynonymsGNT1
hCG_2039726
UGT1
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens . Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps . Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II . Also metabolizes mycophenolate, an immunosuppressive agent . .; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. .

AccessionsQ9HAW9
A9JQZ4
Q5DSZ6
A9JQZ1
A9JQZ2
ENST00000373450.5 [Q9HAW9-1]