UGT1A6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A6 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0046982Molecular functionprotein heterodimerization activity
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameUGT1A6
Protein nameUDP glucuronosyltransferase family 1 member A6
UDP-glucuronosyltransferase (EC 2.4.1.17)
UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)
SynonymsGNT1
hCG_2039726
UGT1
DescriptionFUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). .

AccessionsQ8WUQ4
ENST00000441351.1
H7C5F8
Q5DSZ8
P19224
ENST00000446481.6
ENST00000305139.11 [P19224-1]
ENST00000484784.2
ENST00000373424.5 [P19224-2]
C9JMY5
B5MCT4
ENST00000406651.1