UGT1A5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A5 at tissue level.

III. Associated gene sets

GO_0052695Biological processcellular glucuronidation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0046982Molecular functionprotein heterodimerization activity
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity

IV. Literature review

[source]
Gene nameUGT1A5
Protein nameUDP-glucuronosyltransferase (EC 2.4.1.17)
UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E)
UDP-glucuronosyltransferase 1A5 (EC 2.4.1.17)
SynonymsGNT1
hCG_2039726
UGT1
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II . .; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. .

AccessionsQ5DSZ9
Q5QTE0
Q5QTE1
F5HPU6
Q5QTE3
Q5QTE4
ENST00000373414.4 [P35504-1]
Q5QTE2
P35504
Q5QTD9
Q5QTE5
F5HPU8