UGT1A4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1633.50	226 / 226	79%	56.73	322 / 406
kidney	66%	3.55	59 / 89	1%	0.09	9 / 901
bladder	52%	6.38	11 / 21	1%	0.04	4 / 504
skin	50%	2.87	897 / 1809	0%	0	0 / 472
intestine	34%	6.76	328 / 966	1%	0.15	4 / 527
stomach	33%	1.16	118 / 359	0%	0	0 / 286
esophagus	29%	1.37	412 / 1445	3%	0.03	5 / 183
prostate	21%	0.82	51 / 245	0%	0	0 / 502
lung	10%	0.40	59 / 578	0%	0.01	5 / 1155
peripheral blood	9%	0.64	88 / 929	0%	0	0 / 0
thymus	9%	0.23	58 / 653	0%	0	0 / 605
adrenal gland	8%	0.21	21 / 258	0%	0	0 / 230
adipose	8%	0.53	97 / 1204	0%	0	0 / 0
uterus	7%	0.24	12 / 170	1%	0.05	3 / 459
pancreas	6%	0.15	20 / 328	1%	0.02	2 / 178
spleen	5%	2.60	13 / 241	0%	0	0 / 0
breast	5%	0.12	22 / 459	0%	0.01	3 / 1118
ovary	4%	0.12	8 / 180	0%	0	0 / 430
muscle	3%	0.11	27 / 803	0%	0	0 / 0
blood vessel	3%	0.08	42 / 1335	0%	0	0 / 0
heart	3%	0.13	26 / 861	0%	0	0 / 0
brain	2%	0.07	58 / 2642	0%	0	0 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006789	Biological process	bilirubin conjugation
GO_0070640	Biological process	vitamin D3 metabolic process
GO_0042167	Biological process	heme catabolic process
GO_0052695	Biological process	cellular glucuronidation
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0046982	Molecular function	protein heterodimerization activity
GO_0015020	Molecular function	glucuronosyltransferase activity
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0001972	Molecular function	retinoic acid binding

Gene name	UGT1A4
Protein name	UDP-glucuronosyltransferase UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D) UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase (EC 2.4.1.17)
Synonyms	GNT1 UGT1
Description	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis . Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption . .; FUNCTION: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. .
Accessions	ENST00000450233.1 [P22310-2] B8K2F4 Q0VAJ1 A9UKD8 B8K2F1 B8K2F8 Q8WX87 ENST00000373409.8 [P22310-1] Q53QD2 Q8WX88 B8K2E9 P22310 A9UKD9 Q8WX86 A3KME6 B8K2E8 A9UKD7

UGT1A4 report