UGT1A3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A3 at tissue level.

III. Associated gene sets

GO_0052697Biological processxenobiotic glucuronidation
GO_0006805Biological processxenobiotic metabolic process
GO_0070640Biological processvitamin D3 metabolic process
GO_0052696Biological processflavonoid glucuronidation
GO_0042573Biological processretinoic acid metabolic process
GO_0032782Biological processbile acid secretion
GO_0052695Biological processcellular glucuronidation
GO_0008210Biological processestrogen metabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0046982Molecular functionprotein heterodimerization activity
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameUGT1A3
Protein nameUDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3)
UDP-glucuronosyltransferase
UDP-glucuronosyltransferase (EC 2.4.1.17)
UDP-glucuronosyltransferase 1A3
SynonymsGNT1
hCG_2039726
UGT1
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone . Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption . Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II . .; FUNCTION: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. .

AccessionsQ5DT01
A7ISW3
ENST00000482026.6 [P35503-1]
A9UKC8
A7E1U6
Q8WX90
A7E1U8
Q8WX89
A7E1U7
A7E1U9
B1MV79
Q8WX91
Q75XT5
Q75XT3
P35503
A7E1U5
A9UKC9
A7E1U4
A9UKD1