UGT1A10 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A10 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ureter	0%	0	0 / 0	100%	36.90	1 / 1
intestine	46%	422.86	441 / 966	52%	4.67	273 / 527
stomach	41%	51.81	146 / 359	49%	4.88	140 / 286
esophagus	34%	82.58	487 / 1445	45%	9.87	82 / 183
pancreas	0%	0	0 / 328	72%	16.48	128 / 178
bladder	14%	9.76	3 / 21	49%	17.92	247 / 504
lung	0%	0	0 / 578	19%	5.38	220 / 1155
tonsil	0%	0	0 / 0	13%	2.71	6 / 45
liver	0%	0	0 / 226	13%	2.12	54 / 406
uterus	0%	0	0 / 170	9%	3.97	42 / 459
kidney	0%	0	0 / 89	7%	1.07	66 / 901
prostate	3%	2.29	7 / 245	1%	0.26	4 / 502
lymph node	0%	0	0 / 0	3%	0.19	1 / 29
breast	0%	2.05	1 / 459	1%	0.05	7 / 1118
skin	0%	0.29	8 / 1809	0%	0	0 / 472
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
brain	0%	0	0 / 2642	0%	0	0 / 705
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
thymus	0%	0	0 / 653	0%	0	0 / 605

GO_0051552	Biological process	flavone metabolic process
GO_0001889	Biological process	liver development
GO_0006805	Biological process	xenobiotic metabolic process
GO_0006629	Biological process	lipid metabolic process
GO_0052695	Biological process	cellular glucuronidation
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005080	Molecular function	protein kinase C binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0015020	Molecular function	glucuronosyltransferase activity
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0001972	Molecular function	retinoic acid binding

Gene name	UGT1A10
Protein name	UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) UDP-glucuronosyltransferase (EC 2.4.1.17)
Synonyms	GNT1 hCG_2039726 UGT1
Description	FUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol . Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II . .; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. .
Accessions	ENST00000344644.10 [Q9HAW8-1] ENST00000373445.1 [Q9HAW8-2] Q5DT02 Q9HAW8

UGT1A10 report