UGT1A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT1A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT1A1 at tissue level.

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0006953Biological processacute-phase response
GO_0006805Biological processxenobiotic metabolic process
GO_0070980Biological processbiphenyl catabolic process
GO_0071361Biological processcellular response to ethanol
GO_0071392Biological processcellular response to estradiol stimulus
GO_0052697Biological processxenobiotic glucuronidation
GO_0001889Biological processliver development
GO_0031100Biological processanimal organ regeneration
GO_0042573Biological processretinoic acid metabolic process
GO_0042594Biological processresponse to starvation
GO_0045939Biological processnegative regulation of steroid metabolic process
GO_0006789Biological processbilirubin conjugation
GO_0051552Biological processflavone metabolic process
GO_0052696Biological processflavonoid glucuronidation
GO_0052695Biological processcellular glucuronidation
GO_0008210Biological processestrogen metabolic process
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0008202Biological processsteroid metabolic process
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070069Cellular componentcytochrome complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0034663Cellular componentendoplasmic reticulum chaperone complex
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004857Molecular functionenzyme inhibitor activity
GO_0001972Molecular functionretinoic acid binding
GO_0005496Molecular functionsteroid binding
GO_0046982Molecular functionprotein heterodimerization activity

IV. Literature review

[source]
Gene nameUGT1A1
Protein nameBilirubin UDP-glucronosyltrasferase 1-1
UDP glucuronosyltransferase family 1 member A1
Bilirubin UDP-glucuronosyltransferase
Bilirubin UDP-glucuronosyltransferase 1 A1
UDP-glucuronosyltransferase
Bilirubin UDP-glucuronosyltranserase
UDP glucuronosyltransferase 1 family polypeptide A1 (EC 2.4.1.17)
Bilirubin UDP-glucuronoslytransferase
UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1)
UDP-glucuronosyltransferase (EC 2.4.1.17)
SynonymsGNT1
BILIQTL1
hCG_2039726
UGT1
DescriptionFUNCTION: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol . Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates . Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties . Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II . Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan . .; FUNCTION: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. .

AccessionsQ9BX76
W6JHY2
Q9H3F9
A0A346RP38
W6JGV5
W6JGV8
ENST00000360418.4 [P22309-2]
W6JIA6
P22309
A0A346RP36
ENST00000305208.10 [P22309-1]
Q5DT03
W6JGU4
A0A1L2FNL9
W6JNV6
A0A346RP37
W6JIB0
B6EBF5
A0A0M4UT75
W6JGU6