UBXN6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016236Biological processmacroautophagy
GO_0032510Biological processendosome to lysosome transport via multivesicular body sorting pathway
GO_0036503Biological processERAD pathway
GO_0005813Cellular componentcentrosome
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005768Cellular componentendosome
GO_0031902Cellular componentlate endosome membrane
GO_0005829Cellular componentcytosol
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBXN6
Protein nameUBX domain-containing protein 6 (UBX domain-containing protein 1)
UBX domain protein 6
SynonymsUBXDC2
UBXD1
DescriptionFUNCTION: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes . .

AccessionsQ9BZV1
K7EP32
ENST00000590466.2
K7EJ02
ENST00000394765.7 [Q9BZV1-2]
ENST00000592515.1
K7ELN1
ENST00000591919.5
ENST00000301281.11 [Q9BZV1-1]